Synthetic Biology – Further Reading

This list of links and references accompanies a talk on synthetic biology that was first presented in November 2023 and should encourage further reading.
The current talk is aimed at an audience with some background in molecular biology but may be adjusted upon request for a more general audience.
The list and the talk will be updated when necessary and can be booked (online or live) at info@biowisskomm.de.

BioBricks from iGEM
https://parts.igem.org/Help:An_Introduction_to_BioBricks

Very good paper on DNA writing
https://www.nature.com/articles/s41587-023-02006-0?fbclid=IwAR1ezHZ-169ZuxjvmUUmgXxDobk5NQ43woxeniy1Vvszndhoj3HwGk7Mgp0

Mycoplasma laboratorium, first complete synthetic genome.
https://www.science.org/doi/10.1126/science.1190719.

Movie on DNA methylation by dCas9
https://www.youtube.com/watch?v=XZ5druMJxek

The expanding world of tRNA modifications … (Pay-wall!)
https://www.nature.com/articles/s41580-021-00342-0

Reconstructing biochemical pathways
https://www.biowisskomm.de/en/2023/01/not-quite-a-normal-harvest-1/ (Golden Rice)
https://www.nature.com/articles/nature04640 (Artimisinin – Pay wall!, PDFs on Google scholar)
J. Keasling 2010 DOI: 10.1126/science.1193990

RNA modification by pseudouridine
https://pubmed.ncbi.nlm.nih.gov/18797453/
https://www.biowisskomm.de/2023/10/nobelpreis-fuer-katalin-kariko-und-drew-weissmann-mehr-als-nur-ein-covid-19-impfstoff/ (German)

Extending the genetic code
https://pubs.acs.org/doi/10.1021/acs.biochem.1c00286
https://pharm.ucsf.edu/wang/research/expansion-genetic-code
https://www.mpg.de/489916/pressemitteilung20041209 (German)
unnatural basepairs
https://www.frontiersin.org/articles/10.3389/fmolb.2022.851646/full

Structure of proteins: prediction by AI
https://www.science.org/content/article/game-has-changed-ai-triumphs-solving-protein-structures
https://news.mit.edu/2023/ai-system-can-generate-novel-proteins-structural-design-0420

Structure-function modification
Nobel Lecture by Roger Tsien: https://www.nobelprize.org/prizes/chemistry/2008/tsien/lecture/